Research Network for Metals in Medicine

 

 

Dr Murray Davies

BSc (Hons1) PhD (Syd) MRACI

Position: Lecturer, Inorganic Chemistry

Affiliation: School of Pharmacy and Molecular Sciences, James Cook University

Postal Address:
School of Pharmacy and Molecular Sciences
James Cook University
Douglas Campus
Townsville, Queensland 4811
AUSTRALIA

Phone: +61 (07) 4781 4523
Fax: +61 (07) 4781 6078
Email: Murray.Davies@jcu.edu.au
Webpage: http://www.jcu.edu.au/fmhms/school/pms/chem/staff/Davies/

Research Profile

Bioinorganic Chemistry;

  • The design and DNA binding of Pt anticancer Drugs
  • Mechanism of the toxicity of Pb
  • Structural and magnetic properties of transition metal centres in metalloenzymes

Rates and mechanism of inorganic (and bioinorganic) reactions:
  • Ligand substitution reactions of transition metal complexes
  • mechanism of oxidation (or reduction) of transition metal complexes
  • Evaluation of rate and equilibrium constants from NMR or vibrational spectroscopic data

Molecular Magnetism, magnetic properties or metalloproteins and small inorganic molecules
  • Preparation of multinuclear metal complexes, and examination of their spectroscopic and magnetic behaviour

Current Research Programs
  • Rates and mechanism of binding of Pt(II) and Pt(IV) complexes to DNA .
  • Ligand mediated oxidation of Pt(II)
  • Colorimetric determination of trace metals in biological fluids (with F. R. Keene)
  • Binding of Ca and Pb to dipeptides


Selected Publications

  1. S. J. Berners-Price, M. S. Davies , J. W. Cox, D. S. Thomas and N. Farrell: "Competitive reactions of interstrand and intrastrand DNA-Pt Adducts: A dinuclear-platinum complex preferentially forms a 1,4-interstrand cross-link rather than a 1,2-intrastrand cross-link on binding to a GG 14-mer duplex" Chemistry, A European Journal , 2003 , 9 , 713-725.
  2. M. S. Davies , S. J. Berners-Price, J. W. Cox and N. Farrell: "The nature of the DNA template (single vs double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drug" Journal of the Chemical Society, Chemical Communications, 2003, 122-123.
  3. M. S. Davies , P. -N. Wong, A. R. Battle, G. Haddad, M. J. McKeage and T. W. Hambley: "Examination of the effects of oxidation and ring closure on the cytotoxicities of the platinum complexes of N-(2-hydroxyethyl)ethane-1,2-diamine and ethane-1,2-diamine-N,N'-diacetic acid" Journal of Inorganic Biochemistry, 2002, 91, 205-211.
  4. M. S. Davies, D. S. Thomas, A. Hegmans, S. J. Berners-Price and N. Farrell: "Kinetic and Equilibria studies of the aquation of the trinuclear platinum phase II anticancer agent [{trans-PtCl(NH 3)2}2{m-trans-Pt(NH3)2(NH2(CH2)6NH2)2}]4+ (BBR3464)" Inorganic Chemistry, 2002, 41, 1101-1109.
    5. P. N. Wong, M. S. Davies , T. W. Hambley: "Oxidation of [PtIICl2(ethane-1,2-diamine-N,N'-dicarboxylic acid)] and ligand ring closure in the platinum(IV) oxidation state" Australian Journal of Chemistry, 2001,54, 303-306.
  5. T. W. Hambley, E. C. H. Ling, V. P. Munk and M. S. Davies:" Steric Control of Stereoselective Interactions between the Diastereomeric Platinum(II) Complex, [PtCl2(1,4-diaza-cycloheptane)] and DNA. Comparison with cis-[PtCl2(NH3)2] and [PtCl2(ethane-1,2-diamine)] using DNA Binding and Molecular Modeling Studies" Journal of Biological Inorganic Chemistry, 2001, 5/6, 534-542.
  6. M. S. Davies, C. I. Diakos, B. A. Messerle and T. W. Hambley: "Molecular Conformation of Coordinated Quinoline Ligands and the Rotational Energy Barrier about Pt-N in cis-[PtCl2(quinoline)2] and cis-[PtCl2(3-bromoquinoline)(quinoline)] from X-ray Crystallography, NMR Spectroscopy and Molecular Mechanics Evidence", Inorganic Chemistry, 2001, 40, 3048-3054.
  7. J. W. Cox, S. J. Berners-Price, M. S. Davies, N. Farrell and Y. Qu. "Kinetic Analysis of the Stepwise Formation of a Long Range DNA Interstrand Cross-link by a Dinuclear Platinum Antitumor Complex: Evidence for Aquated Intermediates and Formation of Both Kinetically and Thermodynamically Controlled Conformers.", Journal of the American Chemical Society, 2001, 123, 1316-1326.
  8. M. S. Davies, S. J. Berners-Price and T. W. Hambley: "Cisplatin Aquation is Slowed in the Presence of DNA but not by Phosphate: An Improved Understanding of Sequence Selectivity and the Roles of Monoaquated and Diaquated Species in the Binding of Cisplatin to DNA", Inorganic Chemistry, 2000, 39, 5603-5613.
  9. M. S. Davies, J. W. Cox, S. J. Berners-Price, W. Barklage, Y. Qu and N. Farrell: "Equilibrium and Kinetic Studies of the Aquation of the Dinuclear Platinum Complex [{trans-PtCl(NH3)2}2(m -NH2(CH2)6NH2)]2+ : pKa Determinations of Aqua Ligands via [1H,15N] NMR Spectroscopy", Inorganic Chemistry, 2000, 39, 1710-1715.
  10. M. S. Davies, S. J. Berners-Price and T. W. Hambley: "Rates of Platination of -AG- and -GA- containing double stranded oligonucleotides: effect of chloride concentration", Journal of Inorganic Biochemistry, 2000, 79, 167-172.
  11. M. S. Davies, R. R. Fenton, F. Huq, E. C. H. Ling and T. W. Hambley: "Studies on the Nature and Strength of PtáááH(-N) Interactions. The Crystal Structures of chloro[2,2,2-triaminotriethyl-aminato]platinum(II) chloride and dichloro[1,4,7-triazacyclononaneH]platinum(II) tetrachloroplatinate(II)-2-water and a Molecular Mechanics Analysis of the Pt…H(-N) Interactions", Australian Journal of Chemistry, 2000, 53, 451-457.
  12. E. J. Munson, M. C. Douskey, S. M. De Paul, M. Ziegeweid, L. Phillips, F. Separovic, M. S. Davies and M. J. Aroney: "Variable Temperature One and Two-Dimensional 13C CP/MAS NMR Studies of the Dynamics of Monohaptocyclopentadienyl Rings of Hafnium and Titanium Tetracyclopentadienyl in the Solid State.", Journal of Organometallic Chemistry, 1999,577, 19-23.
  13. M. S. Davies, S. J. Berners-Price and T. W. Hambley: "Rates of Platination of AG and GA Containing Double Stranded Oligonucleotides: Insights into why Cisplatin Binds to GG and AG but not GA Sequences in DNA", Journal of the American Chemical Society, 1998, 120, 11380 - 11390.
  14. T. W. Hambley, S. J. Berners-Price, M. S. Davies, C. I. Diakos, H. M. Er, R. R. Fenton, E. C. H. Ling and E. M. Rezler: "Steric Determinants of Pt/DNA Interactions and Anticancer Activity", Metal Based Drugs, 1998, 5, 197 - 206.
  15. M. S. Davies* and T. W . Hambley: "[Pt2Cl2(m2-O2)2([9]aneN3)2]Cl2: A Novel Platinum(IV) Dimer with Two Bridging Peroxo Ligands that Provides Insight into the Mechanism of Aerial Oxidation of Pt(II)", Inorganic Chemistry, 1998, 37, 5408 - 5409. (Paper was reviewed : K. G. Caulton, Chemtracts, 1999, 581).