Research Network for Metals in Medicine

 

 

Associate Professor David Macey

Position: Associate Professor in Animal Physiology

Affiliation: School of Biological Sciences and Biotechnology, Murdoch University

Postal Address:
Murdoch University
South Street
Murdoch
Western Australia 6150
AUSTRALIA

Phone: +61 (08) 9360 2363
Email: D.Macey@murdoch.edu.au
Webpage: http://wwwscieng.murdoch.edu.au/cgi-bin/phone.cgi?ID=bzbgylzqrx

Research Profile

Assoc Prof. DJ Macey has published extensively over the past 15 years on biological aspects of mineralization in a range of organisms, including lampreys, chitons and limpets together with the human pathology of iron overload diseases. As a physiologist and comparative anatomist, he has a wide range of experience in dealing with animal systems and the collection and maintenance of both invertebrate and vertebrate animals for such studies.

Assoc. Prof. Macey is the senior biologist in an interdisciplinary research group developed at Murdoch, UWA and Curtin for studies of the functional role of iron in mineralizing systems. He has extensive experience in the analysis of tissues, especially at the SEM and TEM level for the presence of biomineralization and coordinates the acquisition of all sample material for the group.

Selected Publications

  1. Lee, A.P. Macey, D.J. and Webb, J. (2001): Molluscan and other marine teeth. In: Encyclopaedia of Materials: Science and Technology. (Eds Cahn, R.W. and Calvert, P.D.) Elsevier Science Ltd., Oxford, 5186-5189. ISBN: 0-08-0431526
  2. Chua-anusorn, W; St. Pierre, TG; Macey, DJ; Webb, J (1998) Reductive changes to polynuclear iron(III) clusters in iron-loaded human spleen tissue. Inorg. Chim. Acta 267 7-10.
  3. St. Pierre, TG; Chua-anusorn, W; Webb, J; Macey, DJ; Pootrakul, P. (1998) The form of iron oxide deposits in thalassemic tissues varies between different groups: a comparison between Thai b-thalassemia/Hemoglobin E patients and Australian b-thalassemia patients. Biochim. Biophys. Acta 1407 51-60.
  4. Lee, AP; Webb, J; Macey, DJ; van Bronswijk, W; Savarese, A; De Witt C (1998) In situ Raman spectroscopic studies of the teeth of the chiton Acanthopleura hirtosa J Biol Inorg.Chem. 3 614-619.
  5. Chua-anusorn, W; Macey DJ; Webb, J; de la Motte Hall P; St.Pierre, TG (1999) Effects of prolonged iron loading in the rat using both parenteral and dietary routes. BioMetals 12 103-113.
  6. Rahman, IHA; Chua-anusorn, W; Webb, J; Macey DJ; St.Pierre, TG (1999) Characterization of dugong liver ferritin. Analyt. Chim. Acta 393 235-243.
  7. Chua-anusorn, W; Webb, J; Macey DJ; de la Motte Hall P; St.Pierre, TG (1999) The effect of prolonged iron loading on the chemical form of iron oxide deposits in rat liver and spleen. Biochim. Biophys. Acta 1454 191-200.
  8. Webb, J; Macey, DJ; Chua-anusorn W; St. Pierre, TG; Brooker, LR; Rahman, I; Noller, B (1999) Iron biominerals in medicine and the environment. Coord. Chem. Rev. 192 1199-1215.
  9. Chua-anusorn, W; Tran, KC; St. Pierre, TG; Macey, DJ; Webb, J (2000) Chemical speciation of iron deposits in thalassemic heart tissue. Inorg. Chim. Acta 300-302 932-936.
  10. St. Pierre, TG; Chua-anusorn, W; Webb, J; Macey, DJ (2000) Iron overload diseases: the chemical speciation of non-heme iron deposits in iron loaded mammalian tissues. Hyperfine Interact. 126 75-81.
  11. Lee, AP; Brooker, LR; Macey, DJ; van Bronswijk, W; Webb, J (2000) Apatite mineralization in the chiton Acanthopleura echinata. Calcif. Tissue Int. 67(5) 408-415.
  12. Trinder, D; Macey DJ; Olynyk JK (2000) The new iron age. Int. J. Molecular Medicine 6(6) 607-612.
  13. Rahman, IHA; Chua-Anusorn, W; Webb, J; Macey, DJ (2000) Elemental analysis of dugong organs. J. Indian Chem. Soc. 77 (11-12) 563-566.
  14. Brooker, LR; Macey DJ (2001) Biomineralization in chiton teeth and its usefulness as a taxonomic character in the genus Acanthopleura Guilding, 1929 (Mollusca: Polyplacophora) Amer. Malacol. Bull. 16 (1/2) 203-215.
  15. Webb, J; Brooker, LR; Lee, AP; Hockridge, J; Liddiard, KJ; Macey, DJ; van Bronswijk, W (2001) Biomineralization-controlled microarchitecture in the radular teeth of chitons and limpets. Aust. J. Chem. 54 611-613.
  16. Brooker, LR; Lee, AP; Macey, DJ; van Bronswijk, W; Webb, J (2003) Multiple-front iron mineralisation in chiton teeth (Mollusca: Polyplacophora). Marine Biology 142 447-454.
  17. Lee, AP; Brooker LR; Macey, DJ; Webb, J; van Bronswijk, W (2003) A new biomineral identified in the cores of teeth from the chiton Plaxiphora albida. Journal of Biological Inorganic Chemistry 8 256-262.
  18. Lee, AP; Brooker, LR; van Bronswijk, W; Macey, DJ; Webb, J (2003) Contribution of Raman spectroscopy to the identification of biominerals present in the teeth of Acanthopleura rehderi, Acanthopleura curtisiana and Onithochiton quercinus. Biopolymers (Biospectroscopy) 72 299-301.
  19. Liddiard, KJ; Hockridge, J; Macey, DJ; Webb, J; van Bronswijk, W (in press) Mineralization in the teeth of the limpets Patella laticostata and Scutellastra alticostata (Mollusca : Patellogastropoda). Molluscan Research

Facilities

light microscopes for the preparation of materials , Philips XL 20 Scanning Electron Microscope and related EDS facilitates, Philips CM 100 Bio and related EDS facilities

International Linkages

Professor Brigid Heywood - Head Dept of Chemistry and Physics, Keele University, UK